Preheat the oven to 350°(F). Spray a 9 x 5 inch baking pan with baking spray and line it with parchment paper. (This is very sticky bread, so you want to use both.)
Cut each biscuit into 6 equal pieces
In a medium-sized microwave-safe bowl, melt butter. Add in pumpkin and pumpkin pie spice. Mix with whisk until well blended and creamy. Add 1 tablespoon of milk, or pumpkin spice creamer. Mix.
In a large bowl, place the cut biscuit pieces. Pour pumpkin mixture over the biscuit dough pieces. Toss to coat with a wooden spoon or silicone spatula.
In a small bowl, mix together the sugar and cinnamon.
Place the coated biscuit pieces in layers in the prepared bread pan. Sprinkle 1/3 of the cinnamon mixture in between each layer of biscuits. You should have 3 layers. Finish with another layer of cinnamon sugar and top with chopped nuts.
Place in the oven, on the center rack, and bake at 350 degrees for 50–65 minutes until golden brown and done.
Remove the bread from the oven, place on the cooling rack, and allow it to cool for 10–15 minutes.
In a small bowl, combine powdered sugar, vanilla, pumpkin pie spice and milk until smooth.
Using a spoon, drizzle the vanilla pumpkin spice glaze over the top of the bread. Serve warm.